Clinical characteristics of ulcerative colitis in the first affiliated Hospital of Guangzhou University of Chinese medicine, China

 Liu Feng-bin1, Thu Nguyen Thi Minh2, Tuyen Pham Ba3, Toan Do Thi Thanh4

1 Department of Gastroenterology, The first Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

2 Postgraduate of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

3 Ministry of Public Security - Traditional Medicine Hospital, Hanoi, Vietnam

4 Hanoi Medical University, Vietnam

 

 

ABSTRACT 

Ulcerative colitis (UC) is a common disease worldwide, and there is a risk for developing colorectal cancer in prolonged UC cases. Recent surveys in China have shown that UC has been increasing in China. This change is attributed to environmental changes.

Objectives

This retrospective analyzed the clinical characteristics of hospitalized patients with UC in The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine for the past 10 years.

Methods

A total of 179 hospitalized patients with UC were admitted at the Department of Gastroenterology in The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from January, 2004 to December, 2013 and were retrospectively investigated and their clinical characteristics were analyzed.

Results

A male/female ratio of 1.00/0.97 was found in the 179 patients within the ages of 12 - 84 years old, an average age of 48.88 ± 16.93 years at diagnosis. The peak at of disease onset was 20 to 60 years. 62.6% of the patients had a disease duration of less than 1 year, while the average disease duration is 2.37 ± 4.00 years. Clinical symptoms were mainly digestive system symptoms such as abdominal pain (82.1%), bloody and mucus stools (68.7%) and diarrhea (45.3%). Among these patients, 55.3% had extraintestinal manifestations of which were mainly moderate and severe degrees, as well as left-sided colitis and proctitis; 5.6% had related complications with colorectal cancer (CRC) between the ages of 41-60 years and over 60 years. Disease severity were mainly mild (40.8%) and moderate (39.1%). Disease stage was mainly in the active stage (79.3%). Lesion extent was mainly proctosigmoiditis (31.8%). Clinical type was mainly chronic relapsing (53.1%).

Conclusion

The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine showed a rising trend year by year of new patients with UC. There were no significance in gender differences. This study also showed that extraintestinal manifestations, lesion extents, disease severity, disease stage, clinical symptoms and clinical types were closely related.

Keywords

Ulcerative colitis, clinical charateristics, restropective analysis

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